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IN VIVO TOXICITY

 toxicology services in mice and rats with endpoints tailored to your needs

Acute toxicity studies characterize the safety of your novel agent after a single administration or multiple administrations within a short period of time.

Acute toxicity studies typically include a 72-hour observation period.

Acute toxicity studies can determine the Maximum Tolerated Dose (MTD), No Observable Effect Level (NOEL), & Optimal Dosing Schedule.

An acute study used in combination with dose range finding studies can guide the design and selection of dose levels for subchronic and chronic toxicity studies.

Follow your acute toxicity studies with subchronic or chronic toxicity studies to evaluate the effects of longterm repeat administrations.

Our team will help you choose the best model and route of exposure, based on clinical relevance. Available routes including oral, subcutaneous, & intravenous are available.  See a complete list of routes at STUDY DESIGNS.

ACUTE & CHRONIC
TOXICITY