IN VIVO EFFICACY
THE IMPORTANCE OF EFFICACY TESTING
Developing new medical treatments is a long and perilous journey with many pitfalls along the way.
Carefully designed efficacy testing is critical to your future success.
The causes and treatments of cancer remain one of the biggest and most demanding areas of clinical treatment in the world. Due to our extensive background in cancer research, Buffalo BioLabs specializes in tumor model development and its applications. Located adjacent to the nation's very first cancer facility, Roswell Park Comprehensive Cancer Center, we are able to work directly with their renowned researchers and clinicians to provide insight on the clinical impact of our clients drug development programs.
Orthotopic implantation of tumor cell lines into the tissue of origin provides a complimentary micro environment to assess efficacy of future treatments against both primary tumor growth as well as metastatic activity.
Subcutaneous models provide a cost effective approach to evaluating novel anticancer drugs. In this popular model type, tumor cells are implanted into the flank of mice or rats where they proliferate to form measurable tumors.
Syngeneic models utilize tumor tissues derived from the same genetic background. As these models use host mice with intact immune systems, they are particularly relevant when testing immune therapies.
Xenograft models involve the implantation of human tumor cells into mice with compromised immune systems that allow mouse tumor cells to grow and allow scientists to evaluate the human tumor response to anticancer drugs.
Survival, cage-side observations, and tumor measurements can be used to evaluate disease progress in any model although some require tumor imaging. Other endpoints such as histopathology and biomarker screening can be combined with tumor models to gain additional insight regarding the efficacy of anticancer therapies. A list of our most common models can be found below.
ADDITIONAL MODELS OF EFFICACY
We offer additional efficacy models of disease as well as model development. Contact us directly to discuss our experience in your area of interest.