Animal Models

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IN VITRO TOXICITY

CYTOTOXICITY, CELL VIABILITY & PROLIFERATION ASSAYS 

Assess a drug’s effect on  growth & viability

Typically performed in multi-well plates

IC50/LC50/EC50 can  help to rank candidates by the strength of a drugs effect 

Numerous readouts are available

COLONY FORMING & CLONOGENIC ASSAYS

Evaluate colony growth in the presence of a toxic substance

Measure differentiation potential in response to stimulatory/inhibitory agents

EX VIVO PBMC ASSAY

A cytotoxicity assay in freshly prepared PBMCs

Examine critical blood cell parameters or specific cytokine levels