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IN VITRO TOXICITY
CYTOTOXICITY, CELL VIABILITY & PROLIFERATION ASSAYS
Assess a drug’s effect on growth & viability
Typically performed in multi-well plates
IC50/LC50/EC50 can help to rank candidates by the strength of a drugs effect
Numerous readouts are available
COLONY FORMING & CLONOGENIC ASSAYS
Evaluate colony growth in the presence of a toxic substance
Measure differentiation potential in response to stimulatory/inhibitory agents
EX VIVO PBMC ASSAY
A cytotoxicity assay in freshly prepared PBMCs
Examine critical blood cell parameters or specific cytokine levels
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